In California and Canada, Citigroup and Leerink Swann are acting as joint book-running managers for Sophiris Bio’s IPO on NASDAC. Stifel and Lazard Capital Markets are acting as co-managers. The offering will be made only by means of a prospectus. When available, copies of the preliminary prospectus relating to and describing the terms of the offering may be obtained from Citigroup Global Markets. Sophiris has filed a registration statement on Form S-1 with the SEC, and a preliminary short form prospectus with the securities regulatory authorities in British Columbia and Ontario. All common shares to be sold in the offering will be offered by Sophiris. The number of shares to be offered and the price range for the offering have not yet been determined.