12 Jul 2016

Full-Time Metabolic Engineering: Scientist III

Lygos – Posted by LygosBerkeley, California, United States

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Job Description


Lygos is an industrial biotechnology startup spun out of the Joint BioEnergy Institute and UC-Berkeley developing microbial pathways for the fermentative production of commodity and specialty chemicals from renewable raw materials. A key focus in the lab is the development of parallelized genetic engineering techniques in yeast to accelerate hypothesis testing and more rapidly identify strains with improved small-molecule production.

The successful applicant will serve as strain architect working on metabolic pathway design and overseeing the rapid design, construction, testing, and screening of genetically engineered yeast strains in an iterative fashion in order to test key hypotheses for improved production of biobased chemicals. Strain characterization, protocol development, and exploratory research will be necessary elements of
the successful applicant’s duties. The successful applicant will be expected to advance critical aspects of Lygos’ metabolic engineering program through both effective individual and team efforts. Research objectives are milestone driven (biocatalyst yield, titer, and productivity) and require workflows directed toward achieving these milestones. It is anticipated that this position will require 80 – 90% time in-lab at
the bench.

– Independently conceive, plan, design and successfully complete metabolic engineering
projects targeting specific nodes of host strain metabolism and/or enzyme activities.
– Deep understanding of yeast cellular physiology and metabolism and the processes associated with target molecule production such as product transport, energy usage, redox metabolism and impact on cellular health.
– Proficiency with techniques used to build DNA libraries, transform eukaryotic microbes and edit microbial genomes.
– Prepare technical reports, quantitative analyses, protocols and scientific presentations.
– Collaboration with all Lygos’ teams, including metabolic engineering, fermentation, and downstream purification groups to interpret integrated process data and find creative solutions to problems.
– Maintain an in-depth knowledge of advances in yeast metabolic engineering and routinely educate fellow team members on critical advances.

– Work to develop strain, enzyme, pathway, and process-related intellectual property.
– Supervise Research Assistants; ensuring team member’s individual discoveries are quickly integrated into optimized host strains.
– There will remain significant time and opportunity to also participate in many other aspects of Lygos’ technical efforts, including: bioinformatics, downstream purification, and other areas of technology development. The Lygos team works closely with all employees to support career development and facilitate the learning of new skill sets.

– Energetic, perseverant and creative team player with a demonstrated ability to plan and execute multiple demanding independent research projects.
– A Ph.D. with an emphasis on yeast metabolic engineering, synthetic biology or metabolite transporter biology with 5+ years of relevant experience, preferably in an industrial setting. Or, an equivalent M.S. with 8+ years of relevant experience.
– Demonstrated success in technical proficiency, scientific creativity, collaborations with others.
– Strong organization skills and proven ability to manage details.

– Strong verbal and written communication skills.
– Ability to deliver on projects and assignments within time frames and budgets.
– Effective problem solver that is willing to work flexibly and take on diverse responsibilities within a start-up company environment.

How to Apply

Please apply at https://lygos.workable.com/jobs/288006.

Job Types: Full-Time.

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