Princeton researchers find fundamental mechanism of isobutanol’s toxic effect

April 28, 2020 |

In New Jersey, in a study published in the journal Cell Systems, researchers from Princeton University revealed a fundamental mechanism of isobutanol’s toxic effect. They found that in the presence of isobutanol, yeast behave like they are starving, even though they are in rich nutritious broth, causing them to slow their growth and metabolism. The team found a key gene that orchestrates this starvation response. Simply deleting this gene enabled the yeast to stave off the chemical’s poisonous effects and pump out isobutanol at much higher levels.

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Category: Research

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